Cell Integration
From IGEM07
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Cell Integration
Increased levels or strength of adherins will cause cells to penetrate into tissue with lower levels of cell-cell interacting molecules. Activation of signaling by binding of one of our signaling targeting chimeric proteins will trigger expression of the cell-cell adhesion molecule N-Cadherin which was inserted downstream of a minimal promoter with lexA operators. Increased N-Cadherin expression may result in penetration of the new cardiomyocytes into the myocardium.
Ilustrative data demonstrating the basic principle from the literature:
