Freiburg University 2006

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== The Team == == The Team ==
-Students:+====Students====
*[[User:Daniel_Hautzinger|Daniel Hautzinger]] *[[User:Daniel_Hautzinger|Daniel Hautzinger]]
*[[User:Marc_Wilnauer|Marc Wilnauer]] *[[User:Marc_Wilnauer|Marc Wilnauer]]
Line 21: Line 21:
*[[User:Mona_Klein|Mona Klein]] *[[User:Mona_Klein|Mona Klein]]
-iGEM instructor:+====iGEM instructor====
*[[User:Andrei_Kouznetsov|Andrei Kouznetsov]] *[[User:Andrei_Kouznetsov|Andrei Kouznetsov]]
-Faculty/staff:+====Faculty/staff====
*[[User:Svetlana_Santer|Svetlana Santer]] *[[User:Svetlana_Santer|Svetlana Santer]]
== The project: DNA Folding== == The project: DNA Folding==
-===Basic Idea:===+===Basic Idea===
====Abstract==== ====Abstract====
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* [http://omnibus.uni-freiburg.de/~kouznet/GS-design.pdf Genetic systems design from the DNA modules] * [http://omnibus.uni-freiburg.de/~kouznet/GS-design.pdf Genetic systems design from the DNA modules]
-== Old project idea==+== Old project ideas==
- +
-* [http://omnibus.uni-freiburg.de/~kouznet/life6000.pdf Life with a price of 6000 €]+
- +
-Now we see it could be cheaper, but it will need a great intellectual impact. So, we’re opened for '''sponsors and relationships'''.+
- +
-=== Comments ===+
- +
-As I understand it, the idea is to create a "life+
-automaton" consisting of 6 proteins? That is what I took+
-out of your proposal. That seems quite ambitioned, but I+
-can't really judge it, and even if it is quite+
-ambitioned, that does not mean that it is bad, of +
-course.+
- +
-My understanding says that you are using 6000 € for +
-denovo synthesis of 6 genes required for making minimal +
-life. Right?+
- +
-So, what if after all the simulations and tests on the +
-computer, you order the DNA for minimal life and it +
-turns out that it doesn't work... What will you do then?+
- +
-This is because biology is unpredictable and you must +
-not assume that the DNA which you order will work in the+
-first time itself... You must keep some backup money or +
-plans...+
- +
-You have to separate specifically the general and specific +
-objectives to long and short time; implications, obstacles +
-and limitations.+
- +
-OK, fine.. So you want to go in a completely different +
-direction by creating alternative life.. Good.. All the +
-best for this project.+
- +
-Well, if you want to go to the extremes then are you +
-limiting yourself to already established phenomena such +
-as DNA, membranes, etc. You may want to adopt a +
-completely new and novel ideas which might be simpler+
-than DNA and other stuff of the normal cell.+
- +
-So, keep all the options open. Research the literature +
-well and create Artificial Life...+
- +
-=== Questions ===+
- +
-* - Dilettante: "Where is a place of synthetic biology here - good old gene engineering > bio-nanotechnology > orthogonal life > artificial life > artificial intelligence?" <br> - Expert: "Hmmm..."+
-* - Professor: "What is new in Synthetic Biology?" <br> - Student: "Wiki!!!"+
-* People on a street: <br> - "What is a synthetic biology - science or technology?" <br> - "Expedition."+
-* - Shrödinger: “What is life?” <br> - Alice: “It’s a play where rules are constantly changed.”+
 +* [[Life_6000 Life with a price of 6000 €]]
== Hey Mutant, have a look! == == Hey Mutant, have a look! ==

Revision as of 21:07, 28 August 2006

Welcome! We are Alife Mutants.

Image:uf101.jpg

This term was invented by Martin Schneider on the Rule 110 Winter Workshop in 2004 [1]. We play without rules. We discover the rules that govern life, the universe and everything to exploit these rules and to create Artificial Life. Our short-time aim is the trip to Boston in November 2006 to take a prize in the iGEM.

Image:Freiburg_Team_06.JPG

The Freiburg Team (well, at least half of it...) from left to right: Irina Petrova, Andrei Kouznetsov, Daniel Hautzinger.


Contents

The Team

Students

iGEM instructor

Faculty/staff

The project: DNA Folding

Basic Idea

Abstract

The idea is to design a strand of DNA such that it wraps into some meaningful shape. There are three different stages for this project: First, the DNA should fold into a two-dimensional rectangular sheet. Secondly, this sheet should wrap itself up into the shape of a short pipe. And last, these little pipes should hook themselves up to each other such that they form one single long pipe.

Scetches - Pipes

Pipes - Stage 1
Enlarge
Pipes - Stage 1
Pipes - Stage 2
Enlarge
Pipes - Stage 2
Pipes - Stage 3
Enlarge
Pipes - Stage 3


The DNA sequence for the Pipes design can be found here.

Application: Barbie Nanoatelier

Once the process of DNA folding into 3D-structures is understood, shapes can be chosen arbitrarily. The idea of the Barbie Nanoatelier is that the DNA should wrap into a 3D-TShirt, 3D-Pants, etc.

Scetches - TShirt

TShirt - Stage 1
Enlarge
TShirt - Stage 1
TShirt - Stage 2
Enlarge
TShirt - Stage 2
TShirt - Stage 3
Enlarge
TShirt - Stage 3
TShirt - Stage 4
Enlarge
TShirt - Stage 4


Scetches - Bluse

Bluse - Stage 1
Enlarge
Bluse - Stage 1
Bluse - Stage 2
Enlarge
Bluse - Stage 2


The DNA sequence for the Bluse design can be found here.

GEM Freiburg

Club

SB Preliminary

Old project ideas

Hey Mutant, have a look!

The easy and serious way

These people do great things

Albert Libchaber [2] Carlos Bustamante's lab [3] David Deamer [4] Eric Kool’s group [5] Erik Winfree [6] Fred Menger’s group [7] Jack Szostak’s lab [8] Norman Packard’s Protolife [9] Pier Luigi Luisi’s group [10] Radhika Nagpal [11] Steven Benner’s group [12]

Local

An Analysis of Synthetic Biology Research in Europe and North America [13] DNA synthesis: ATG-Biosynthetics [14]

Bold text

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Past/present/future years